Journal
ONCOLOGY REPORTS
Volume 34, Issue 6, Pages 2821-2826Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2015.4288
Keywords
liver kinase B1; AMP-activated protein kinase; TGF-beta signal transduction; tumor invasion; metastasis
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Funding
- National Natural Science Foundation of China [8117195, 81272926, 31460304, 81460374]
- Jiangxi Provincial Department of Health [20155117, 20155145]
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Liver kinase B1 (LKB1), also known as serine/threonine kinase 11 (STK11), is a tumor suppressor that is inactivated in Peutz-Jeghers familial cancer syndrome. LKB1 phosphorylates and activates AMP-activated protein kinase (AMPK), which negatively regulates cancer cell proliferation and metabolism. However, recent evidence demonstrates that the LKB1/AMPK pathway is involved in the process of tumor invasion and migration, which is an important hallmark of carcinoma progression to higher pathological grades of malignancy. This review focuses on the function of the LKB1/AMPK pathway in the invasion and migration of cancer cells and provides an overview of therapeutic strategies aimed at this pathway in malignant tumors.
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