Journal
JOURNAL OF EXPERIMENTAL NANOSCIENCE
Volume 10, Issue 12, Pages 911-924Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17458080.2014.933493
Keywords
in vitro study; deep eutectic solvent; gum arabic; gold nanoparticles; X-ray contrast agent
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Funding
- Research Councils of Shiraz University of Medical Sciences
- Research Council of Shiraz University, Shiraz, Iran
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This paper reports a novel method of fabricating gum arabic coated gold nanoparticles (GA-GNPs) synthesised in a deep eutectic solvent (DES) for use as a new X-ray contrast agent. GA-GNPs were prepared simply by mixing a solution of 0.01% DES, GA and tetra chloroauric (III) acid at room temperature. DES was prepared using choline chloride (ChCl), gallic acid and glycerol as the precursors. A complete characterisation study of GA-GNPs was undertaken using transmission electron microscopy, dynamic light scattering, X-ray diffraction analysis. In vitro study of the as-prepared GA-GNPs revealed the high potential of these nanoparticles as X-ray contrast agents. Compared with the common clinically available CT contrast agent, Visipaque, the synthesised GA-GNPs showed more than three fold X-ray attenuation coefficient. GA-GNPs were found to be remarkably stable in biological media. The development of such nontoxic, biocompatible nanostructures could be an advancement in diagnostic nanomedicine.
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