Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 215, Issue 8, Pages 2019-2034Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20180427
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Funding
- Special Coordination Funds for Promoting Science and Technology of the Japanese government
- Astellas Pharma Inc.
- Japanese Ministry of Education, Culture, Sports, Science, and Technology [22790479, 25111506, 16H02632]
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Health and Labor Sciences Research Grants for Research on Intractable Diseases from the Ministry of Health, Labor, and Welfare of Japan
- RIKEN Government Funding for Operations
- RIKEN Integrated Symbiology
- Grants-in-Aid for Scientific Research [16H02632, 22790479, 25111506] Funding Source: KAKEN
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Immunoglobulin A (IgA) promotes health by regulating the composition and function of gut microbiota, but the molecular requirements for such homeostatic IgA function remain unknown. We found that a heavily glycosylated monoclonal IgA recognizing ovalbumin coats Bacteroides thetaiotaomicron (B. theta), a prominent gut symbiont of the phylum Bacteroidetes. In vivo, IgA alters the expression of polysaccharide utilization loci (PUL), including a functionally uncharacterized molecular family provisionally named Mucus-Associated Functional Factor (MAFF). In both mice and humans, MAFF is detected predominantly in mucus-resident bacteria, and its expression requires the presence of complex microbiota. Expression of the MAFF system facilitates symbiosis with other members of the phylum Firmicutes and promotes protection from a chemically induced model of colitis. Our data reveal a novel mechanism by which IgA promotes symbiosis and colonic homeostasis.
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