Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 210, Issue 3, Pages 491-502Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20122006
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Funding
- Intramural Research Program of the National Institute for Allergy and Infectious Disease
- National Institutes of Health
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Here, we show that interleukin-1 (IL-1) enhances antigen-driven CD8 T cell responses. When administered to recipients of OT-I T cell receptor transgenic CD8 T cells specific for an ovalbumin (OVA) peptide, IL-1 results in an increase in the numbers of wild-type but not IL1R1(-/-) OT-I cells, particularly in spleen, liver, and lung, upon immunization with OVA and lipopolysaccharide. IL-1 administration also results in an enhancement in the frequency of antigen-specific cells that are granzyme B+, have cytotoxic activity, and/ or produce interferon gamma (IFN-gamma). Cells primed in the presence of IL-1 display enhanced expression of granzyme B and increased capacity to produce IFN-gamma when rechallenged 2 mo after priming. In three in vivo models, IL-1 enhances the protective value of weak immunogens. Thus, IL-1 has a marked enhancing effect on antigen-specific CD8 T cell expansion, differentiation, migration to the periphery, and memory.
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