Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 209, Issue 3, Pages 597-606Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20111696
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Funding
- National Institutes of Health [R01 AI036914, R37 AI027998, T32 CA009138, F32 AI091033]
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Memory B cells can be produced from the classical germinal center (GC) pathway or a less understood GC-independent route. We used antigen-based cell enrichment to assess the relative contributions of these pathways to the polyclonal memory B cell pool. We identified a CD38(+) GL7(+) B cell precursor population that differentiated directly into IgM(+) or isotype-switched (sw) Ig(+) memory B cells in a GC-independent fashion in response to strong CD40 stimulation. Alternatively, CD38(+) GL7(+) B cell precursors had the potential to become Bcl-6(+) GC cells that then generated primarily swIg(+) memory B cells. These results demonstrate that early IgM(+) and swIg(+) memory B cells are products of a GC-independent pathway, whereas later switched Ig(+) memory B cells are products of GC cells.
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