Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 208, Issue 6, Pages 1189-1201Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20101823
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Funding
- National Institutes of Health [5R01AI079243-02, 5K08CA133521]
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Excessive or inappropriate activation of the immune system can be deleterious to the organism, warranting multiple molecular mechanisms to control and properly terminate immune responses. MicroRNAs (miRNAs), similar to 22-nt-long noncoding RNAs, have recently emerged as key posttranscriptional regulators, controlling diverse biological processes, including responses to non-self. In this study, we examine the biological role of miR-146a using genetically engineered mice and show that targeted deletion of this gene, whose expression is strongly up-regulated after immune cell maturation and/or activation, results in several immune defects. Collectively, our findings suggest that miR-146a plays a key role as a molecular brake on inflammation, myeloid cell proliferation, and oncogenic transformation.
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