Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 207, Issue 9, Pages 1807-1817Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20101157
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Funding
- Nationals Institutes of Health
- American Asthma Foundation
- Goldhirsh Foundation
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Everyday we turnover billions of cells. The quick, efficient, and immunologically silent disposal of the dying cells requires a coordinated orchestration of multiple steps, through which phagocytes selectively recognize and engulf apoptotic cells. Recent studies have suggested an important role for soluble mediators released by apoptotic cells that attract phagocytes (find-me signals). New information has also emerged on multiple receptors that can recognize phosphatidylserine, the key eat-me signal exposed on the surface of apoptotic cells. This perspective discusses recent exciting progress, gaps in our understanding, and the conflicting issues that arise from the newly acquired knowledge.
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