Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 207, Issue 10, Pages 2045-2048Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20101866
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The tumor suppressor gene p53 prevents the initiation of tumor formation by inducing cell cycle arrest, senescence, DNA repair, and apoptosis. Recently, the absence or mutation of p53 was described to facilitate nuclear reprogramming. These findings suggest an influence of p53 on the de-differentiation process, and highlight the similarities between induction of pluripotency and tumor formation.
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