Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 207, Issue 5, Pages 911-913Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20100608
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The nonreceptor tyrosine kinase SYK has recently received a good deal of attention as a critical oncogene in various hematologic malignancies. A newly developed model of peripheral T cell lymphoma (PTCL) using the ITK-SYK fusion gene should serve as a powerful tool to dissect the signaling cascades important for SYK-associated malignancy in the context of t(5;9) PTCL.
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