Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 206, Issue 8, Pages 1673-1680Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20082460
Keywords
-
Categories
Funding
- Dutch Organization for Scientific Research [ZONMW 912-03-048, ZONMW-VENI 016.066.093]
- European commission [EEG LSHB-CT-2006-018996]
- National Institutes of Health [Al073462, Al072296]
Ask authors/readers for more resources
Soluble egg antigens of the parasitic helminth Schistosoma mansoni (S. mansoni egg antigen [SEA]) induce strong Th2 responses both in vitro and in vivo. However, the specific molecules that prime the development of Th2 responses have not been identified. We report that omega-1, a glycoprotein which is secreted from S. mansoni eggs and present in SEA, is capable of conditioning human monocyte-derived dendritic cells in vitro to drive T helper 2 ( Th2) polarization with similar characteristics as whole SEA. Furthermore, using IL-4 dual reporter mice, we show that both natural and recombinant omega-1 alone are sufficient to generate Th2 responses in vivo, even in the absence of IL-4R signaling. Finally, omega-1-depleted SEA displays an impaired capacity for Th2 priming in vitro, but not in vivo, suggesting the existence of additional factors within SEA that can compensate for the omega-1-mediated effects. Collectively, we identify omega-1, a single component of SEA, as a potent inducer of Th2 responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available