Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 206, Issue 8, Pages 1653-1660Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20090246
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Funding
- National Institutes of Health [AI048667]
- Medical Research Council [G0600698B] Funding Source: researchfish
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We report that like other T cells cultured in the presence of transforming growth factor (TGF)beta, Th17 cells also produce interleukin (IL) 9. Th17 cells generated in vitro with IL-6 and TGF-beta as well as purified ex vivo Th17 cells both produced IL-9. To determine if IL-9 has functional consequences in Th17-mediated inflammatory disease, we evaluated the role of IL-9 in the development and progression of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. The data show that IL-9 neutralization and IL-9 receptor deficiency attenuates disease, and this correlates with decreases in Th17 cells and IL-6-producing macrophages in the central nervous system, as well as mast cell numbers in the regional lymph nodes. Collectively, these data implicate IL-9 as a Th17-derived cytokine that can contribute to inflammatory disease.
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