Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 206, Issue 7, Pages 1495-1503Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20090681
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Funding
- Ligue Nationale contre le Cancer (Equipe labelisee La Ligue)
- Agence Nationale de la Recherche
- Institut National de la Sante et de la Recherche Medicale
- Centre National de la Recherche Scientifique
- Ministere de l'Enseignement Superieur et de la Recherche
- Associazione Italiana per la Ricerca sul Cancro
- Istituto Superiore di Sanita
- Ministero della Sanita
- Ministero dell'Istruzione
- dell'Universita e della Ricerca Scientifica e Tecnologica
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Cancer development is often associated with the lack of specific and efficient recognition of tumor cells by the immune system. Natural killer (NK) cells are lymphocytes of the innate immune system that participate in the elimination of tumors. We report the identification of a tumor cell surface molecule that binds NKp30, a human receptor which triggers antitumor NK cell cytotoxicity and cytokine secretion. This previously unannotated gene belongs to the B7 family and, hence, was designated B7-H6. B7-H6 triggers NKp30-mediated activation of human NK cells. B7-H6 was not detected in normal human tissues but was expressed on human tumor cells, emphasizing that the expression of stress-induced self-molecules associated with cell transformation serves as a mode of cell recognition in innate immunity.
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