Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 206, Issue 13, Pages 2861-2864Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20092469
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The progressive rise in the prevalence of allergic diseases since the 1970s is widely attributed to diminished exposure to microbial stimuli, resulting in dysregulated immune functions during early life. Most studies investigating the mechanism behind this phenomenon have focused on postnatal microbial exposure. But emerging evidence suggests that such programming may also occur in the developing fetus as a result of microbial stimulation of the pregnant mother.
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