Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 206, Issue 12, Pages 2671-2683Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20091802
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Funding
- Terry Fox Cancer Foundation
- Canadian Institutes of Health Research [MOP 67157]
- Natural Sciences and Engineering Research Council of Canada
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B cell activation factor of the TNF family (BAFF) activates noncanonical nuclear factor kappa B (NF-kappa B) heterodimers that promote B cell survival. We show that although MALT1 is largely dispensable for canonical NF-kappa B signaling downstream of the B cell receptor, the absence of MALT1 results in impaired BAFF-induced phosphorylation of NF-kappa B2 (p100), p100 degradation, and RelB nuclear translocation in B220(+) B cells. This corresponds with impaired survival of MALT1(-/-) marginal zone (MZ) but not follicular B cells in response to BAFF stimulation in vitro. MALT1(-/-) MZ B cells also express higher amounts of TRAF3, a known negative regulator of BAFF receptor-mediated signaling, and TRAF3 was found to interact with MALT1. Furthermore, phenotypes associated with overexpression of BAFF, including increased MZ B cell numbers, elevated serum immunoglobulin titers, and spontaneous germinal center formation, were found to be dependent on B cell-intrinsic MALT1 expression. Our results demonstrate a novel role for MALT1 in biological outcomes induced by BAFF-mediated signal transduction.
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