Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 205, Issue 9, Pages 1959-1965Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20080526
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Funding
- [R01-AI50659]
- [R01-AI43576]
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Mice with a T cell-specific deletion of Prdm1, encoding Blimp-1, have aberrant T cell homeostasis and develop fatal colitis. In this study, we show that one critical activity of Blimp-1 in T cells is to repress IL-2, and that it does so by direct repression of Il2 transcription, and also by repression of Fos transcription. Using these mechanisms Blimp-1 participates in an autoregulatory loop by which IL-2 induces Prdm1 expression and thus represses its own expression after T cell activation, ensuring that the immune response is appropriately controlled. This activity of Blimp-1 is important for cytokine deprivation induced T cell death and for attenuating T cell proliferation in antigen-specific responses both in vitro and in vivo.
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