Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 205, Issue 2, Pages 271-274Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20080167
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- Intramural NIH HHS Funding Source: Medline
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Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of bacterial infections in the United States. Severe invasive MRSA infections, which include pneumonia, are difficult to treat because the bacteria are resistant to antibiotics. A new report now shows that immunization against alpha-hemolysin (Hla), a cytolytic toxin secreted by most S. aureus strains, protects mice against lethal pneumonia. This finding represents the first successful vaccine strategy for the treatment of staphylococcal pneumonia.
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