Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 205, Issue 6, Pages 1251-1254Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20081057
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Antibody diversity is first generated by rearrangement of immunoglobulin (Ig) genes during B cell development in the bone marrow, and later by antigen-driven diversification in germinal centers (GCs). New data in humans and mice now identify specific B cell populations that may have undergone antigen-independent hypermutation outside GCs.
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