Journal
ONCOGENE
Volume 35, Issue 16, Pages 2011-2019Publisher
SPRINGERNATURE
DOI: 10.1038/onc.2015.304
Keywords
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Funding
- National Natural Science Foundation of China [30971330, 31371420, 81320108024, 81000861, 81322036, 81272383]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81421001]
- Program for Innovative Research Team of Shanghai Municipal Education Commission
- Shanghai 'Oriental Scholars' project [2013XJ]
- Shanghai Science and Technology Commission 'Pujiang Project' [13PJ1405900]
- Shanghai Natural Science Foundation [12ZR1417900]
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Colorectal cancer (CRC) results from the accumulation of genetic alterations, and somatic copy number alterations (CNAs) are crucial for the development of CRC. Genome-wide survey of CNAs provides opportunities for identifying cancer driver genes in an unbiased manner. The detection of aberrant CNAs may provide novel markers for the early diagnosis and personalized treatment of CRC. A major challenge in array-based profiling of CNAs is to distinguish the alterations that play causative roles from the random alterations that accumulate during colorectal carcinogenesis. In this view, we systematically discuss the frequent CNAs in CRC, focusing on functional genes that have potential diagnostic, prognostic and therapeutic significance.
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