Journal
JOURNAL OF EXPERIMENTAL BIOLOGY
Volume 214, Issue 7, Pages 1148-1152Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jeb.053496
Keywords
oxidative stress; vertebrates; oxidative damage; antioxidants; modularity; network
Categories
Funding
- NERC [NE/G013888/1]
- Natural Environment Research Council [NE/G013888/1] Funding Source: researchfish
- NERC [NE/G013888/1] Funding Source: UKRI
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Integration is a property of biological systems that refers to the extent to which their components are correlated through functional, structural, developmental or evolutionary interdependency. This study examined patterns of functional integration among different molecular components of the blood redox system (both plasma and red blood cells) in zebra finches (Taeniopygia guttata). Our results show a two cluster organization of the six measured variables: one cluster includes glutathione peroxidase in both red blood cells and plasma, thiol concentration in red blood cells and plasma hydroperoxides; the other cluster comprises a measure of the non-enzymatic antioxidant capacity in red blood cells and plasma. The interaction network amongst these variables shows (i) a strong positive connectivity among hydroperoxides, glutathione peroxidase and thiols, and (ii) negative connectivity between non-enzymatic and enzymatic antioxidants. Overall, our results also suggest strong and significant integration between the oxidative state of red blood cells and plasma.
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