4.2 Article

Is the weighted z-test the best method for combining probabilities from independent tests?

Journal

JOURNAL OF EVOLUTIONARY BIOLOGY
Volume 24, Issue 4, Pages 926-930

Publisher

WILEY-BLACKWELL
DOI: 10.1111/j.1420-9101.2010.02226.x

Keywords

combined probabilities; Fisher test; generalized Fisher test; meta-analysis; Stouffer's method; weighted z-test

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Through simulation, Whitlock showed that when all the alternatives have the same effect size, the weighted z-test is superior to both unweighted z-test and Fisher's method when combining P-values from independent studies. In this paper, we show that under the same situation, the generalized Fisher method due to Lancaster outperforms the weighted z-test.

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