Journal
JOURNAL OF EVOLUTIONARY BIOLOGY
Volume 22, Issue 10, Pages 2125-2129Publisher
WILEY
DOI: 10.1111/j.1420-9101.2009.01830.x
Keywords
deleterious mutations; disease; host-parasite interactions; selection; stress
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Funding
- Natural Sciences and Engineering Research Council of Canada
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In natural populations, fitness is reduced by both deleterious mutations and parasites. Few studies have examined interactions between these two factors, particularly at the level of individual genes. We examined how the presence of a bacterial pathogen, Pseudomonas aeruginosa, affected the selection against each of eight deleterious mutations in Drosophila melanogaster. We found that mutations tended to become more deleterious in the presence of disease. This increase in the average selection was primarily due to three genes with the remainder showing little evidence of change.
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