Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 152, Issue 3, Pages 508-521Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2014.01.032
Keywords
Dracaena cochinchinensis SC Chen; Chinese Dragon's Blood; Therapeutic agents for neurodegenerative diseases; Polymers; NQO1 inducing activity; Anti-inflammatory effect
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Funding
- National Natural Science Foundation of China [81173531, 81102432]
- Training Programme Foundation for the Distinguished Young Scholars of University in Liaoning Province [LJQ2012088]
- Nature Science Foundation of Liaoning Province [2013020183]
- Program for Innovative Research Team of the Ministry of Education
- Program for Liaoning Innovative Research Team in University
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Ethnopharmacological relevance: Dragon's blood has been used as a famous traditional medicine since ancient times by many cultures. It is a deep red resin, obtained from more than 20 different species of four distinct genera. Red resin of Dracaena cochinchinensis S.C. Chen, known as Chinese Dragon's Blood or Yunnan Dragon's Blood, has been shown to promote blood circulation, alleviate inflammation, and to treat stomach ulcers, diarrhea, diabetes, and bleeding. This study investigated an effective approach to identify natural therapeutic agents for neurodegeneration from herbal medicine. The dichloride extract and isolated effective constituents of Chinese Dragon's Blood showed quinone oxidoreductase 1 (NQO1) inducing activity and anti-inflammatory effect significantly, which are therapy targets of various neurodegenerative diseases. Materials and methods: Multiple chromatography and spectra analysis were utilized to afford effective constituents. Then Hepa 1c1c7 and BV-2 cells were employed to assay their NQO1 inducing and anti-inflammatory activities, respectively. Results: Bioactivities guided isolation afforded 21 effective constituents, including two new polymers cochinchinenene E (I), cochinchinenene F (2) and a new steroid dracaenol C (16). The main constituent 3 (weight percent 0.2%), 5 (weight percent 0.017%), 4 (weight percent 0.009%), 9 (weight percent 0.094%), 10 (weight percent 0.017%) and 8 (weight percent 0.006%) are responsible for the anti-inflammatory activities of Chinese Dragon's Blood. While, new compounds 1, 2 and known compounds 5, 11 showed good NQO1 inducing activities. The brief feature of the activities and structures was discussed accordingly. Conclusion: Overviewing the bioactivities and phytochemical study result, 4'-hydroxy-2,4-dimethoxydihydrochalcone (3) and pterostilbene (5) as effective constituents of Chinese Dragon's Blood, were found to be potential candidate therapeutic agents for neurodegenerative diseases. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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