4.7 Article

Regulation effects on abnormal glucose and lipid metabolism of TZQ-F, a new kind of Traditional Chinese Medicine

Journal

JOURNAL OF ETHNOPHARMACOLOGY
Volume 128, Issue 3, Pages 575-582

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2010.01.044

Keywords

Abnormal glucose and lipid metabolism; Paeonia lactiflora; Morus alba; Nelumbo nucifera; Salvia miltiorrhiza; Crataegus pinnatifida

Funding

  1. Ministry of Education of China [706019]
  2. International Traditional Chinese Medicine Program for Corporation in Science and Technology [2009DFA31070]
  3. Ministry of Science and Technology of China [2009ZX09102-128, 2009ZX09311-002]

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Aim of the study: Based on the recipe of the traditional anti-diabetic formula TZQ we developed TZQ-F, a new formula including 8 fractions isolated from Red Paeony root, Mulberry leaf, Lotus leaf, Danshen root and Hawthorn leaf with a good quality assurance. The study was aimed at fraction preparation and effects of the fractions on abnormal glucose and lipid metabolism. Materials and methods: The active fractions were obtained by macroporous resin, ion-exchange resin and polyamide resin column chromatographies. HPLC analyses were used for quality control. In vitro mechanism study included DPPH radical scavenging, AGEs formation inhibition, a-glucosidase inhibition and lipase inhibition, and rats on high-fat diet were used for in vivo study. Results: In vitro mechanism study showed that among the 8 fractions, three of them had inhibition effects on intestinal disaccharase, three with inhibition effects on lipase, and five with effects of free radical scavenging. In vivo study showed that after 4 weeks of treatment, TZQ-F significantly decreased the levels of serum total cholesterol, TG, glucose, LDL-C and HDL-C in rats on high-fat diet. Consistent with the in vitro and in vivo results, histology study demonstrated that TZQ-F alleviated hepatic steatosis induced by high-fat diet. Conclusions: TZQ-F possesses the potential regulation effects on abnormal glucose and lipid metabolism. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

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