Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 124, Issue 3, Pages 339-349Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2009.05.019
Keywords
Bridelia; Drug discovery screening; Indigenous medicine; Pain treatment
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Approximately 60 species of Bridelia, (Phyllanthaceae) are found throughout tropical and subtropical regions of the world, mainly in Africa and Asia. Several Bridelia species are used in popular medicines as antiamebic, antianemic, antibacterial, anticonvulsant, anti-diabetic, antidiarrhoeal, antihelmintic, anti-inflammatory, antimalarial, anti nociceptive, antiviral, hypoglycemic and for abdominal pain, cardiovascular, gynecological and sexual diseases. The present paper reviews the traditional usage, the biological activities and the correlated chemical compounds of Bridelia species with emphasis on the validation of the ethnopharmacological uses. The findings in some Bridelia species of, for example, gallocatechin(4'-O-7)-epigallocatechin (1), quercetin (2), myricetin glycosides (5-6), bridelone (11), bridelonine (12), isoflavone may justify the uses of these species against pains in African and Asian traditional medicines. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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