Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals

Aim of the study: The ethanol extract (LF) of Ligularia fischeri var. spiciformis (leaf) has been evaluated for antinociceptive and anti-inflammatory activities in mice. Materials and Methods: Analgesic and anti-inflammatory activities were studied by measuring nociception induced by formalin, acetic acid and hot-plate, and inflammation induced by carrageenan, formalin, and arachidonic acid. Results: The acute treatment of mice with LF at doses of 100 and 200 mg/kg, by oral administration, produced a significant antinociceptive effect in the acetic acid-induced writhing, formalin-induced pain licking and hot-plate-induced pain. Also, the LF significantly inhibited both carrageenan- and formalin-induced inflammation as well as arachidonic acid-induced ear edema in mice. Conclusions: These inhibitions were statistically significant (P < 0.05). Thus, our investigation suggests a potential benefit of Ligularia-fischeri in treating conditions associated with inflammatory pain. (C) 2008 Elsevier Ireland Ltd. All rights reserved.