Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 116, Issue 1, Pages 161-166Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2007.11.020
Keywords
Helicteres isora (Sterculiaceae); streptozotocin; lipoprotein levels; hypolipidaemic effect
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In this study, the hypolipidaemic effect of an aqueous extract of the bark of Helicteres isora was investigated in streptozotocin (STZ)-induced diabetic rats. Administration of the bark extract of Helicteres isora (100 and 200 mg/kg b.w.) for 21 days resulted in significant reduction in serum and tissue cholesterol, phospholipids, free fatty acids and triglycerides in STZ diabetic rats. In addition to that, significant (p < 0.05) decrease in high-density lipoprotein (HDL) whereas significant increase (p < 0.05) low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were observed in STZ diabetic rats, which were normalized after 21 days of bark extract treatment. The bark extract at a dose of 200 mg/kg b.w. showed much significant hypolipidaemic effect than at the dose of 100 mg/kg b.w. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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