Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 116, Issue 1, Pages 198-203Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2007.11.034
Keywords
Nyctanthes arbortristis L.; anti-inflammatory activity; antinociceptive activity
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Nyctanthes arbortristis Linn is a well-documented plant. It is evident from literature and previous investigations that Nyctanthes arbortristis possesses anti-inflammatory and analgesic activity. In the present study arbortristoside-A has been isolated from the ethanolic extract of its seeds. The structure of the isolated compound was determined by chemical reactions and spectroscopic methods. Arbortristoside-A was found to possess significant and dose-dependent anti-inflammatory and antinociceptive activity. It seems arbortristoside-A inhibited the histamine, serotonin and carrageenan-induced edema suggesting its inhibiting effect on carrageenan, arachidonic acid, histamine and serotonin-induced edema suggesting its anti-inflammatory activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. The analgesic activity of arbortristoside-A may be due to the inhibition of the action of prostaglandin. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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