Journal
JOURNAL OF ESSENTIAL OIL BEARING PLANTS
Volume 12, Issue 6, Pages 728-741Publisher
HAR KRISHAN BHALLA & SONS
DOI: 10.1080/0972060X.2009.10643782
Keywords
Penetration enhancer; E. bungei; extract; essential oil; piroxicam; percutaneous; GC-MS
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Funding
- research council of the Mazandaran University of Medical Sciences
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Recently, in order to improve drug permeation through the skin, penetration enhancers have attracted a great deal of interest in increasing percutaneous absorption. Natural compounds like terpenes have been suggested as promising non-toxic, non-irritating transdermal penetration enhancers. This investigation aimed to study the effect of extract and essential oil of Eryngium bungei (as a traditional anti-inflammatory and antinociceptive) on the transdermal absorption of piroxicam. The stable gel was chosen and enhancing effects of plant extract and essential oil with different concentrations (0.5 - 3.0 and 0.25 - 5.0% w/w respectively) on the permeation of piroxicam were evaluated. The results showed that the greatest enhancement of the skin transport occurs at the highest concentration of the enhancer (P < 0.01). The most outstanding penetration enhancer was plant essential oil in 5% w/w, providing an almost 9.17-fold increase in permeability coefficient of piroxicam.
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