Journal
JOURNAL OF EPIDEMIOLOGY
Volume 23, Issue 6, Pages 429-434Publisher
JAPAN EPIDEMIOLOGICAL ASSOC
DOI: 10.2188/jea.JE20130048
Keywords
mucocutaneous lymph node syndrome; long-term prognosis; mortality rate; follow-up; Japan
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Funding
- Japan Society for the Promotion of Science [22390137]
- Grants-in-Aid for Scientific Research [22390137] Funding Source: KAKEN
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Background: The long-term outcomes of Kawasaki disease (KD) are unknown. Methods: Fifty-two collaborating hospitals collected data on all patients who had received a new definite diagnosis of KD between July 1982 and December 1992. Patients were followed until December 31, 2009 or death. Standardized mortality ratios (SMRs) were calculated based on Japanese vital statistics data. Results: Of the 6576 patients enrolled, 46 (35 males and 11 females) died (SMR: 1.00; 95% CI: 0.73-1.34). Among persons without cardiac sequelae, SMRs were not high after the acute phase of KD (SMR: 0.65; 95% CI: 0.41-0.96). Among persons with cardiac sequelae, 13 males and 1 female died during the observation period (SMR: 1.86; 95% CI: 1.02-3.13). Conclusions: In this cohort, the mortality rate among Japanese with cardiac sequelae due to KD was significantly higher than that of the general population. In contrast, the rates for males and females without sequelae were not elevated.
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