Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 29, Issue 5, Pages 647-653Publisher
INFORMA HEALTHCARE
DOI: 10.3109/14756366.2013.837899
Keywords
Anti-bacterial; methicillin-resistant Staphylococcus aureus; rhodanine
Funding
- National Science Foundation of China [81260468]
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Herein, we report the design, syntheses and in vitro anti-microbial activity of two series of rhodanines with chalcone moiety. Anti-microbial tests showed that some of the synthesized compounds exhibited good inhibition (MIC = 1-8 mu g/mL) against multi-drug-resistant Gram-positive organisms, including methicillin resistant and quinolone-resistant Staphylococcus aureus, in which the compound 4g was found to be the most potent with minimum inhibitory concentration (MIC) value of 1 mu g/mL against two methicillin-resistant S. aureus.
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