Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 28, Issue 6, Pages 1205-1210Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2012.723207
Keywords
Antidiabetic drugs; 2,4-thiazolidinediones; imidazolidine-2,4-diones; 2-thioxo-imidazolidine-4-ones; chromonyl-2,4-thiazolidinediones; insulinotropic activity
Funding
- Research Organization of Ankara University, Turkey [09B3336003]
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Numerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, we report the synthesis and the in vitro insulin releasing activity of the 6-methyl-chromonyl-2,4-thiazolidinediones (IIIa-c, IVa-c, Va-c). Compounds IIIb, IIIc, IVa-c, Va and Vc (at lower concentration; 0.001 mg/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose. In this series, the most potent compound is IVa having methyl group at N3 position of TZD ring.
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