Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 27, Issue 5, Pages 646-648Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2011.604853
Keywords
Pistagremic acid; leishmanicidal; Pistacia integerrima
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The present study was designed to investigate the whole plant of Pistacia integerrima Stewart in order to examine the pharmacological basis of the use of the plant in folk medicine for the treatment of infectious diseases and disorder. Phytochemical and pharmacological studies led to the isolation of a new triterpene pistagremic acid (3-methyl-7-(4,4,10,13,14-pentamethyl-3-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-oct-3-enoic). Pistagremic acid showed significant leishmanicidal activity (IC50: 6.71 +/- 0.09 mu M) against Leishmania major (DESTO) promastigotes in comparison to standard compound amphotericin B (IC50: 0.21 +/- 0.06 mu M).
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