4.6 Article

Preparation of some pyrazoline derivatives and evaluation of their antifungal activities

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Publisher

TAYLOR & FRANCIS LTD
DOI: 10.3109/14756360903373368

Keywords

Pyrazoline; antifungal activity; Candida spp.

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The synthesis of a new series of 1-[( benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-( chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by H-1-NMR, C-13-NMR, and FAB(+)-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed.

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