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Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
MI Koukourakis et al.
BRITISH JOURNAL OF CANCER (2003)
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
M Hirsilä et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma
A Chrastina et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
CPS Potter et al.
BRITISH JOURNAL OF CANCER (2003)
Regulation of angiogenesis by hypoxia: role of the HIF system
CW Pugh et al.
NATURE MEDICINE (2003)
The hypoxia-inducible factor-1α is a negative factor for tumor therapy
A Unruh et al.
ONCOGENE (2003)
Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas
M Nordsmark et al.
RADIOTHERAPY AND ONCOLOGY (2003)
Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 uhiquitin ligase complex
MA Maynard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Carbonic anhydrase inhibitors
CT Supuran et al.
MEDICINAL RESEARCH REVIEWS (2003)
Pre-mRNA splicing and human disease
NA Faustino et al.
GENES & DEVELOPMENT (2003)
Molecular (functional) imaging for radiotherapy applications: An RTOG symposium
JD Chapman et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2003)
Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
DEB Swinson et al.
JOURNAL OF CLINICAL ONCOLOGY (2003)
Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin
E Svastova et al.
EXPERIMENTAL CELL RESEARCH (2003)
Hypoxia-inducible factor 1 alpha is essential for cell cycle arrest during hypoxia
N Goda et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Combining bioreductive drugs and radiation for the treatment of solid tumors
IJ Stratford et al.
SEMINARS IN RADIATION ONCOLOGY (2003)
Functional cellular assays with multiparametric silicon sensor chips
M Brischwein et al.
LAB ON A CHIP (2003)
Microenvironmental and cellular consequences of altered blood flow in tumours
N Raghunand et al.
BRITISH JOURNAL OF RADIOLOGY (2003)
Therapeutic advantage from combining paclitaxel with the hypoxia-selective cytotoxin NLCQ-1 in murine tumor- or human xenograft-bearing mice
MV Papadopoulou et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2002)
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors
HLK Janssen et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2002)
Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9
PM Loadman et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α
C Koumenis et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1α
DA Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Phosphorous metabolites and steady-state energetics of transformed fibroblasts during three-dimensional growth
LA Kunz-Schughart et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3α locus
Y Makino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Tumor microenvironment and the response to anticancer therapy
JM Brown
CANCER BIOLOGY & THERAPY (2002)
Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys
C Rosenberger et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2002)
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours
AV Patterson et al.
GENE THERAPY (2002)
HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron
SJ Mandriota et al.
CANCER CELL (2002)
Assessment of hypoxia in experimental mice tumours by [18F]fluoromisonidazole PET and pO2 electrode measurements -: Infuence of tumour volume and carbogen breathing
L Bentzen et al.
ACTA ONCOLOGICA (2002)
Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans
PA Padilla et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Hypoxia - A key regulatory factor in tumour growth
AL Harris
NATURE REVIEWS CANCER (2002)
Hypoxia as a target for combined modality treatments
BG Wouters et al.
EUROPEAN JOURNAL OF CANCER (2002)
Radiobiological characteristics of solid tumours depending on the p53 status of the tumour cells, with emphasis on the response of intratumour quiescent cells
S Masunaga et al.
EUROPEAN JOURNAL OF CANCER (2002)
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
Y Makino et al.
NATURE (2001)
Structure and function of the radical enzyme ribonucleotide reductase
H Eklund et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2001)
The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N
R Gallagher et al.
BRITISH JOURNAL OF CANCER (2001)
Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma
SK Chia et al.
JOURNAL OF CLINICAL ONCOLOGY (2001)
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
GL Semenza
TRENDS IN MOLECULAR MEDICINE (2001)
Schedule-dependent potentiation of chemotherapeutic drugs by the bioreductive compounds NLCQ-1 and tirapazamine against EMT6 tumors in mice
MV Papadopoulou et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2001)
Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells role of the p22phox-containing NADPH oxidase
A Görlach et al.
CIRCULATION RESEARCH (2001)
Oxygen deprivation causes suspended animation in the zebrafish embryo
PA Padilla et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Mitochondrial DNA in human malignancy
JS Penta et al.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2001)
Hypoxia in human soft tissue sarcomas:: Adverse impact on survival and no association with p53 mutations
M Nordsmark et al.
BRITISH JOURNAL OF CANCER (2001)
Biological consequences of tumor hypoxia
M Höckel et al.
SEMINARS IN ONCOLOGY (2001)
Hypoxia inhibits G1/S transition through regulation of p27 expression
LB Gardner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Semiquantitative immunohistochemical analysis for hypoxia in human tumors
JA Raleigh et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2001)
p21Cip1 and p27Kip1 regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest
SL Green et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Efficient translation of mouse hypoxia-inducible factor-1α under normoxic and hypoxic conditions
A Görlach et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2000)
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
KL Talks et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
The relative importance of NADPH:: Cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions
MP Saunders et al.
BIOCHEMICAL PHARMACOLOGY (2000)
Metabolic imaging in multicellular spheroids of oncogene-transfected fibroblasts
S Walenta et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2000)
Identification of alternative spliced variants of human hypoxia-inducible factor-1α
E Gothié et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice
PM Loadman et al.
BIOCHEMICAL PHARMACOLOGY (2000)
Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine
OP Friery et al.
BRITISH JOURNAL OF CANCER (2000)