Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 24, Issue 2, Pages 457-463Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360802188628
Keywords
Ruthenium (II) complexes; polypyridines; anti-tubercular activity
Funding
- Ministry of Education of Morocco [PGR-UMP-BH-2005, CUD-UMP-BH-2007]
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A series of nine polypyridyl-ruthenium (II) complexes (N-ligands=2,2'-bipyridines; 2,2'-6',2'-terpyridines, di-alkyloxy-2,2'-6,2-bipyridine-3,3'-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1-10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds.
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