Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 23, Issue 5, Pages 728-738Publisher
INFORMA HEALTHCARE
DOI: 10.1080/14756360802208251
Keywords
N-pyridinyl and N-pyridinylmethyl-indole-1-or-3-propanamides and propenamides; topical and systemic inflammation inhibitors
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In this study, the synthetic way to new N-pyridinyl(methyl)indolylpropanamides acting as non acidic NSAIDs has been described. Pharmacomodulation was carried out at N(1) and C(5) of the indole ring and at the level of the propanamide chain. N(3)-pyridinylmethyl-[1(4-chlorobenzyl-5-chloroindol-3-yl)propanamide represents one of the most potent compounds in the TPA-induced mouse ear swelling assay, with a level of activity higher than that of ibuprofen and comparable to that of dexamethasone.
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