Journal
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
Volume 48, Issue 7, Pages 791-799Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10934529.2013.744650
Keywords
Paracetamol; biodegradation; Pseudomonas aeruginosa strain HJ1012; mineralization; kinetics; metabolic pathway
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Funding
- National Natural Science Foundation of China [50908210, 21177116]
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Pseudomonas aeruginosa strain HJ1012 was isolated on paracetamol as a sole carbon and energy source. This organism could completely degrade paracetamol as high as 2200mg/L. Following paracetamol consumption, a CO2 yield rate up to 71.4% proved that the loss of paracetamol was mainly via mineralization. Haldane's equation adequately described the relationship between the specific growth rate and substrate concentration. The maximum specific growth rate and yield coefficient were 0.201g-Paracetamol/g-VSS center dot h and 0.101mg of biomass yield/mg of paracetamol consumed, respectively. A total of 8 metabolic intermediates was identified and classified into aromatic compounds, carboxylic acids, and inorganic species (nitrite and nitrate ions). P-aminophenol and hydroquinone are the two key metabolites of the initial steps in the paracetamol catabolic pathway. Paracetamol is degraded predominantly via p-aminophenol to hydroquinone with subsequent ring fission, suggesting partially new pathways for paracetamol-degrading bacteria.
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