Urinary 8-iso-prostaglandin F2 as a marker of metabolic risks in the general Japanese population: The ROAD study

ObjectiveTo determine whether 8-iso-prostaglandin F2 (8-iso-PGF2) is a reliable biomarker of the accumulation of metabolic risks [e.g., overweight, hypertension, impaired glucose tolerance (IGT), and dyslipidemia]. MethodsThis was a cross-sectional study of the baseline characteristics of a Japanese general population cohort study: Research on Osteoarthritis/Osteoporosis Against Disability (ROAD). Of 1,690 participants, 1,527 fulfilled all questionnaires and examinations. Free and conjugated urinary 8-iso-PGF2 levels and metabolic syndrome (MetS) components including blood pressure, HbA1c, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and non-HDL-C were analyzed. The data were analyzed by ANCOVA, multiple regression analysis, and multinomial logistic analysis. Results8-iso-PGF2 was significantly associated with HbA1c and significantly inversely associated with total cholesterol and non-HDL-C. Notably, IGT with an HbA1c cut-off of 5.5% was significantly associated with 8-iso-PGF2 level in participants aged 50 years. Multinomial logistic regression analysis revealed 8-iso-PGF2 level was significantly associated with a greater number of MetS risks present; this association was stronger in younger participants. In participants aged 71 years, 8-iso-PGF2 was significantly associated with a greater number of MetS risks with higher IGT cut-offs. ConclusionsUrinary 8-iso-PGF2 can be a reliable marker of IGT and the accumulation of MetS risks, especially in younger people.