Journal
JOURNAL OF ENDOCRINOLOGY
Volume 223, Issue 1, Pages T9-T23Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/JOE-14-0264
Keywords
leptin; leptin receptor; structure; modeling
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Funding
- IUAP [P6/36]
- Research Foundation-Flanders (FWO-V) [G.0521.12N]
- ERC [340941]
- European Research Council (ERC) [340941] Funding Source: European Research Council (ERC)
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Leptin plays a central role in the control of body weight and energy homeostasis, but is a pleiotropic cytokine with activities on many peripheral cell types. In this review, we discuss the interaction of leptin with its receptor, and focus on the structural and mechanistic aspects of the extracellular aspects of leptin receptor (LR) activation. We provide an extensive overview of all structural information that has been obtained for leptin and its receptor via X-ray crystallography, electron microscopy, small-angle X-ray scattering, homology modeling, and mutagenesis studies. The available knowledge is integrated into putative models toward a recapitulation of the LR activation mechanism.
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