Journal
JOURNAL OF ENDOCRINOLOGY
Volume 217, Issue 1, Pages 83-94Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/JOE-12-0469
Keywords
VEGF; uterine cervical growth and immune cell recruitment
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Funding
- Appalachian State University Office of Student Research and the Graduate School
- Grants-in-Aid for Scientific Research [23406037] Funding Source: KAKEN
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Knowledge of uterine cervical epithelial biology and factors that influence its events may be critical in understanding the process of cervical remodeling (CR). Here, we examine the impact of exogenous vascular endothelial growth factor (VEGF) on uterine cervical epithelial growth in mice (nonpregnant and pregnant) treated with VEGF agents (recombinant and inhibitor) using a variety of morphological and molecular techniques. Exogenous VEGF altered various uterine cervical epithelial cellular events, including marked induction of growth, edema, increase in inter-epithelial paracellular space, and recruitment of immune cells to the outer surface of epithelial cells (cervical lumen). We conclude that VEGF induces multiple alterations in the uterine cervical epithelial tissues that may play a role in local immune surveillance and uterine cervical growth during CR.
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