4.5 Review

5α-Reduced glucocorticoids: a story of natural selection

Related references

Note: Only part of the references are listed.
Review Public, Environmental & Occupational Health

Steroid 5-alpha-Reductase Type 2 (SRD5a2) Gene Polymorphisms and Risk of Prostate Cancer: A HuGE Review

Jun Li et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2010)

Article Endocrinology & Metabolism

Failure of isolated rat tibial periosteal cells to 5α reduce testosterone to 5α-dihydrotestosterone

Russell T. Turner et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2010)

Article Biochemistry & Molecular Biology

Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations

Guillaume A. Schoch et al.

JOURNAL OF MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride

Kazutoshi Yamana et al.

HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION (2010)

Article Endocrinology & Metabolism

Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency

Dawn E. W. Livingstone et al.

JOURNAL OF ENDOCRINOLOGY (2009)

Review Endocrinology & Metabolism

Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids

Karolien De Bosscher et al.

MOLECULAR ENDOCRINOLOGY (2009)

Article Endocrinology & Metabolism

Depot-specific steroidogenic gene transcription in human adipose tissue

Scott M. MacKenzie et al.

CLINICAL ENDOCRINOLOGY (2008)

Article Biochemistry & Molecular Biology

Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene

Claudia Unterberger et al.

MOLECULAR IMMUNOLOGY (2008)

Review Endocrinology & Metabolism

Drug Insight: selective agonists and antagonists of the glucocorticoid receptor

Andrew McMaster et al.

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM (2008)

Article Multidisciplinary Sciences

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice

Roberto C. Agis-Balboa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Endocrinology & Metabolism

Effects of gonadectomy on glucocorticoid metabolism in obese Zucker rats

Pascal Barat et al.

ENDOCRINOLOGY (2007)

Review Endocrinology & Metabolism

Glucocorticoid-induced osteoporosis: pathophysiology and therapy

E. Canalis et al.

OSTEOPOROSIS INTERNATIONAL (2007)

Article Biochemistry & Molecular Biology

Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone

Emily B. Askew et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Endocrinology & Metabolism

The effect of 5α reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men

John K. Amory et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

Article Endocrinology & Metabolism

Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity

Deborah J. Wake et al.

CLINICAL ENDOCRINOLOGY (2007)

Article Biochemistry & Molecular Biology

Mouse 3 alpha-hydroxy steroid dehydrogenase mRNA: A marker of lung maturity

Pierre R. Provost et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)

Article Rheumatology

Patterns of cardiovascular risk in rheumatoid arthritis

D. H. Solomon et al.

ANNALS OF THE RHEUMATIC DISEASES (2006)

Article Endocrinology & Metabolism

Variants in the 5α-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women

Mark O. Goodarzi et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Article Multidisciplinary Sciences

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis

Roberto C. Agis-Balboa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Endocrinology & Metabolism

Steroid 5α-reductase isozymes in the adult female rat brain:: central role of dihydrotestosterone

JM Torres et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2006)

Article Neurosciences

Localization of 5α-reductase in the rat main olfactory bulb

E Kiyokage et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2005)

Article Endocrinology & Metabolism

Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging

F Hammer et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

Article Multidisciplinary Sciences

A fully dissociated compound of plant origin for inflammatory gene repression

K De Bosscher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Endocrinology & Metabolism

Increased A-ring reduction of glucocorticoids in obese Zucker rats: Effects of insulin sensitization

DEW Livingstone et al.

OBESITY RESEARCH (2005)

Article Endocrinology & Metabolism

Influence of short-term dietary weight loss on cortisol secretion and metabolism in obese men

AM Johnstone et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2004)

Article Multidisciplinary Sciences

Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

H Schäcke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Recognition and accommodation at the androgen receptor coactivator binding interface

E Hur et al.

PLOS BIOLOGY (2004)

Article Medicine, General & Internal

Taking glucocorticoids by prescription is associated with subsequent cardiovascular disease

L Wei et al.

ANNALS OF INTERNAL MEDICINE (2004)

Article Pharmacology & Pharmacy

Androgen metabolism in thymus of fetal and adult rats

J Borlak et al.

DRUG METABOLISM AND DISPOSITION (2004)

Article Biochemistry & Molecular Biology

5α-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor

KJ McInnes et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Endocrinology & Metabolism

Developmental Expression and Regulation of Aromatase- and 5α-Reductase Type 1 mRNA in the Male and Female Mouse Hypothalamus

Magdalena Karolczak et al.

JOURNAL OF NEUROENDOCRINOLOGY (2003)

Article Endocrinology & Metabolism

Androgen 5-alpha-reductase type 2 is highly expressed and active in rat spinal cord motor neurones

P Pozzi et al.

JOURNAL OF NEUROENDOCRINOLOGY (2003)

Article Endocrinology & Metabolism

Beyond adrenal and ovarian androgen generation:: Increased peripheral 5α-reductase activity in women with polycystic ovary syndrome

M Fassnacht et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Article Endocrinology & Metabolism

A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects

MJ Coghlan et al.

MOLECULAR ENDOCRINOLOGY (2003)

Article Endocrinology & Metabolism

Differential regulation of rat testicular 5α-reductase type 1 and 2 isoforms by testosterone and FSH

K Pratis et al.

JOURNAL OF ENDOCRINOLOGY (2003)

Article Biochemistry & Molecular Biology

Physiological characteristics of allo-cholic acid

ME Mendoza et al.

JOURNAL OF LIPID RESEARCH (2003)

Article Endocrinology & Metabolism

Altered cortisol metabolism in polycystic ovary syndrome: Insulin enhances 5 alpha-reduction but not the elevated adrenal steroid production rates

T Tsilchorozidou et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Article Endocrinology & Metabolism

Human osteoblast-like cells express predominantly steroid 5α-reductase type 1

S Issa et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)

Article Biochemistry & Molecular Biology

Distribution and metabolism of 20α-hydroxylated progestins in the female rat

FV Nowak

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2002)

Review Endocrinology & Metabolism

The epidemiology of corticosteroid-induced osteoporosis: A meta-analysis

TP van Staa et al.

OSTEOPOROSIS INTERNATIONAL (2002)

Article Biochemistry & Molecular Biology

Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

HM Reichardt et al.

EMBO JOURNAL (2001)

Article Endocrinology & Metabolism

Unexpected virilization in male mice lacking steroid 5α-reductase enzymes

MS Mahendroo et al.

ENDOCRINOLOGY (2001)

Article Cell Biology

Glucocorticoid receptor activation of the IκBα promoter within chromatin

BJ Deroo et al.

MOLECULAR BIOLOGY OF THE CELL (2001)

Article Endocrinology & Metabolism

5α-Reductases in human breast carcinoma:: Possible modulator of in situ androgenic actions

T Suzuki et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2001)

Article Endocrinology & Metabolism

Characterization of the 5α-reductase-3α-hydroxysteroid dehydrogenase complex in the human brain

S Steckelbroeck et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2001)

Article Endocrinology & Metabolism

Tissue-specific dysregulation of cortisol metabolism in human obesity

E Rask et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2001)

Article Dermatology

Immunolocalization of 5 alpha-reductase isozymes in acne lesions and normal skin

D Thiboutot et al.

ARCHIVES OF DERMATOLOGY (2000)

Article Ophthalmology

Identification of androgen receptor protein and 5 alpha-reductase mRNA in human ocular tissues

EM Rocha et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2000)