Journal
JOURNAL OF ENDOCRINOLOGY
Volume 198, Issue 2, Pages 261-269Publisher
SOC ENDOCRINOLOGY
DOI: 10.1677/JOE-08-0170
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Funding
- NIAMS NIH HHS [R01 AR050626, R01 AR037399-20, R01 AR037399, R01 AR050626-05] Funding Source: Medline
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Our perception of the vitamin D system continues to evolve. Recent studies have re-evaluated the parameters for adequate vitamin D status in humans, revealing a high prevalence of insufficiency In many populations throughout the world. Other reports have highlighted the potential consequences of vitamin D insufficiency beyond established effects oil bone homeostasis. Most notably there is now strong evidence of a role for vitamin D in modulating innate and adaptive immunities, with insufficiency being linked to infectious disease and other immune disorders. To date, signaling pathways For these new responses to vitamin D have been based oil established endocrine models for active 1,25-dihydroxyvitamin D, despite present evidence for more localized, intracrine modes of action. In the following review, we provide a fresh perspective on vitamin D signaling in non-classical target cells Such as macrophages by highlighting novel factors associated with the transport and action of this pluripotent secosteroid.
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