Journal
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
Volume 32, Issue 7, Pages 597-600Publisher
SPRINGER
DOI: 10.1007/BF03346515
Keywords
Adrenocortical carcinoma; adrenocortical neoplasm; beta-catenin; BRAF; mutation analysis; oncogene
Categories
Funding
- University of Padova
Ask authors/readers for more resources
Background: Activating mutations of the BRAF oncogene play a central role in the development of various cancer types, but their role in human adrenocortical tumors is unknown. At variance, activating mutations of another oncogene, CTNNB1, which encodes beta-catenin, have been shown to be common events in both benign and malignant adrenocortical tumors. Aim: To investigate the prevalence of BRAF and CTNNB1 activating mutations in sporadic adrenocortical tumors. Materials and methods: Tissue samples from 15 adrenocortical carcinomas and 41 adrenocortical adenomas were investigated for the presence of BRAF and CTNNB1 activating mutations by PCR amplification and direct sequencing. Results: An advanced invasive non-functioning adrenocortical carcinoma carried a somatic heterozygous BRAF V600E mutation, while 4 functioning and 4 non-functioning adenomas and 3 functioning carcinomas carried different CTNNB1 activating mutations. Conclusions: Activating BRAF somatic mutations may be occasionally found in advanced adrenocortical carcinomas, while CTNNB1 activating mutations are early and common events in adrenal tumorigenesis. (J. Endocrinol. Invest. 32: 597-600, 2009) (C) 2009, Editrice Kurtis
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available