Journal
JOURNAL OF EMERGENCY MEDICINE
Volume 44, Issue 4, Pages 764-772Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jemermed.2012.07.055
Keywords
ACEI; angioedema; bradykinin; FFP
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Background: Angioedema secondary to angiotensin-converting enzyme inhibitors (ACEI) is a commonly encountered problem in the Emergency Department (ED). The treatment of ACEI-induced edema with conventional methods such as epinephrine, steroids, and antihistamines is usually not effective. There is limited experience using bradykinin receptor blockers and fresh frozen plasma (FFP) as a treatment modality for ACEI-induced angioedema. Objective: To emphasize alternative treatment option for ACEI-induced angioedema in the ED. Case Reports: We report a case series of progressive and refractory presumed ACEI-induced angioedema that all improved in temporal association with administration of FFP, with a brief review of the literature. Conclusion: There was a temporal association between the administration of FFP and improvement in angioedema in seven cases of presumed ACEI-induced angioedema that were refractory to antihistamines, corticosteroids, and epinephrine. Published by Elsevier Inc.
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