Journal
NUTRITION JOURNAL
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12937-016-0167-8
Keywords
Nutritional immunology; Resveratrol; Immune modulation; NK cell activity; Innate immune system
Categories
Funding
- German Childhood Cancer Foundation (DKS) [2012.14, 2014.19]
- Wissenschaftsfoerderung der Deutschen Brauwirtschaft e.V. (Wifoe) [B103]
- PASCOE pharmazeutische Praeparate GmbH
- Institutional Strategy of the Eberhard Karls University of Tuebingen (Deutsche Forschungsgemeinschaft (DFG) [ZUK 63]
- DFG
- Open Access Publishing Fund of the Eberhard Karls University of Tuebingen
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Natural killer (NK) cells as part of the innate immune system represent the first line of defence against (virus-) infected and malignantly transformed cells. The emerging field of nutritional immunology focuses on compounds featuring immune-modulating activities in particular on NK cells, which e.g. can be exploited for cancer prevention and treatment. The plant-based nutrition resveratrol is a ternary hydroxylated stilbene, which is present in many foods and beverages, respectively. In humans it comprises a large variety of distinct biological activities. Interestingly, resveratrol strongly modulates the immune response including the activity of NK cells. This review will give an overview on NK cell functions and summarize the resveratrol-mediated modulation thereof.
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