Increased plasma selenium is associated with better outcomes in children with systemic inflammation

Objective: The aim of this study was to assess the effects of changes in plasma selenium on the outcome of critically ill children. Methods: Plasma selenium was prospectively measured in 99 children with acute systemic inflammation. The exposure variables were selenium level on admission and on day 5 of stay in the intensive care unit (ICU) and the difference in selenium concentrations between day 5 post-admission and the ICU admission (delta selenium). Selenium was given only as part of enteral diets. Age, malnutrition, red cell glutathione peroxidase-1 activity, serum C-reactive protein, Pediatric Index of Mortality 2, and Pediatric Logistic Organ Dysfunction scores were analyzed as covariates. The outcome variables were ventilator-free days, ICU-free days, and 28-d mortality. Results: Plasma selenium concentrations increased from admission (median 23.4 mu g/L, interquartile range 12.0-30.8) to day 5 (median 25.1 mu g/L, interquartile range 16.0-39.0; P = 0.018). After adjustment for confounding factors, a delta selenium increase of 10 mu g/L was associated with reductions in ventilator days (1.3 d; 95% confidence interval [CI], 0.2-2.3; P = 0.017) and ICU days (1.4 d; 95% CI, 0.5-2.3; P < 0.01). Delta selenium >0 was associated with decreased 28-d mortality on a univariate model (odds ratio, 0.67; 95% Cl, 0.46-0.97; P = 0.036). The mean daily selenium intake (6.82 mu g; range 0-48.66 mu g) was correlated with the increase in selenium concentrations on day 5. Conclusions: An increase in plasma selenium is independently associated with shorter times of ventilation and ICU stay in children with systemic inflammation. These findings raise the hypothesis that selenium supplementation could be beneficial in children with critical illnesses. (C) 2015 Elsevier Inc. All rights reserved.