Journal
NUTRITION
Volume 31, Issue 2, Pages 283-291Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2014.08.011
Keywords
Nutrients; Polyunsaturated fatty acids; Vitamins; Pyridoxine; Lipoxins; Resolvins; Protectins; Heart failure; Atherosclerosis; Coronary artery disease; Nitric oxide; Asymmetrical dimethylarginine; Magnesium; Eicosanoids; Arrhythmias; Cytokines; L-arginine
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Funding
- Ramalingaswami Fellowship of the Department of Biotechnology, New Delhi
- Department of Biotechnology (DBT) [BT/PR11627/MED/30/157/2010]
- Department of Science and Technology under Intensification of Research in High Priority Areas (IRPHA) [IR/SO/LU/03/2008/1]
- Defence Research and Development Organisation, New Delhi [TC/2519/INM-03/2011/CARS, INM-311]
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Nutritional factors such as magnesium, folic acid, vitamins B-12 and B-6, L-arginine, and polyunsaturated fatty acids (PUFAs) appear to be significantly beneficial for patients with coronary artery disease (CAD), and in the prevention and arresting the progression of HF and cardiac arrhythmias. Additionally, ingestion of adequate amounts of protein and maintaining normal concentrations of plasma albumin seem to be essential for these patients. These nutrients closely interact with the metabolism of L-arginine-nitric oxide (NO) system, essential fatty acids, and eicosanoids such that beneficial products such as NO, prostaglandin E-1, prostacyclin, prostaglandin I-3, lipoxins, resolvins, and protectins are generated and synthesis of proinflammatory cytokines is suppressed that results in platelet anti-aggregation, vasodilation, angiogenesis, and prevention of CAD, cardiac arrhythmias, and stabilization of HF. This implies that individuals at high risk for CAD, cardiac arrhythmias, and HF and those who have these diseases need to be screened for plasma levels of magnesium, folic acid, vitamins B-12 and B-6, L-arginine, NO, various PUFAs, lipoxin A(4), resolvins, protectins, asymmetrical dimethylarginine (an endogenous inhibitor of NO), albumin, and various eicosanoids and cytokines and correct their abnormalities to restore normal physiology. (C) 2015 Elsevier Inc. All rights reserved.
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