Journal
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
Volume 709, Issue -, Pages 106-110Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jelechem.2013.10.006
Keywords
Supramolecular assembly; Perylene derivatives; Electrochemiluminescence; Immunosensor; Peroxydisulfate
Categories
Funding
- NNSF of China [21275119, 21105081, 21075100]
- Research Fund for the Doctoral Program of Higher Education (RFDP) [20110182120010]
- Ministry of Education of China [708073]
- Specialized Research Fund for the Doctoral Program of Higher Education [20100182110015]
- Natural Science Foundation Project of Chongqing City [CSTC-2010BB4121, CSTC-2011BA7003]
- Fundamental Research Funds for the Central Universities, China [XDJK2010C062, XDJK2012 A004]
Ask authors/readers for more resources
A novel electrochemiluminescent immunosensor was designed for cancer biomarker detection based on peroxydisulfate cathodic electrochemiluminescence using a new enhancer, one kind of perylene derivatives, synthesized by integrating the arginine covalently onto the 3,4,9,10-perylenetetracarboxylic acid (PTCA) (abbreviation as PTC-Arg). Combining the supramolecular assembly method, the aromatic compound of PTC-Arg was effectively immobilized on the gold nanoparticles functionalized graphene (Au@Gra) by pi-pi stacking (PTC-Arg/Au@Gra). And then PTC-Arg/Au@Gra complexes were further used as multifunctional nanocarriers for the absorption of the second antibody of alpha-fetoprotein (Ab(2)), which formed sandwich-type immunoassay format through associating with alpha-fetoprotein (AFP) and the first antibody (Ab(1)). With PTC-Arg/Au@Gra as enhancer of peroxydisulfate system, the immunosensor exhibited a wide dynamic range of 0.001-10 ng mL(-1) and detection of limits (LODs) of 0.3 pg mL(-1), respectively. It also suggested a great potential development and applications for sensitive bioassays in clinical detection. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available