Journal
JOURNAL OF ECT
Volume 30, Issue 4, Pages 320-324Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YCT.0000000000000096
Keywords
transcranial magnetic stimulation; major depression; neuropsychological function
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Funding
- National Institute of Mental Health [RO1 MH 62154, R25 MH60486]
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Early studies of transcranial magnetic stimulation (TMS) have shown no adverse effects on neuropsychological function. However, further research using higher TMS intensities as well as a greater number of TMS pulses and with larger sample sizes is needed. We studied 68 patients with major depressive disorder who were randomized to receive either 15 sessions of sham or real TMS at 110% of the estimated prefrontal cortex threshold to the left dorsolateral prefrontal cortex. Each session consisted of 32 5-second trains of 10-Hz repetitive TMS at 110% adjusted motor threshold. A total of 24,000 pulses were given. Neuropsychological function was assessed before and immediately after TMS treatment with a battery of 8 tests. Using a higher TMS intensity as well as a greater number of pulses and having a larger sample size compared with most previous studies, this study found no negative neuropsychological effects of TMS. Changes in neuropsychological function were unrelated to changes in depression.
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