Journal
JOURNAL OF ECT
Volume 24, Issue 2, Pages 114-116Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YCT.0b013e31815f65b9
Keywords
seizure threshold; major depression; bilateral ECT
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The seizure threshold (ST) is a measure of the minimum electrical energy necessary to induce a grand mal seizure. Dose titration of the ST has been suggested to optimize stimulus dosing in electroconvulsive therapy (ECT). The change in ST with remission is examined in a large sample of unipolar depressed patients. Methods: In a study of. continuation treatments after successful ECT, the ST was determined at the first treatment and again 1 week after remission using a conventional ST measurement protocol. Patients were treated with bilateral electrode placement at 150% above the measured ST. Results: In 80 subjects, the ST measured the same in 70%, increased in 21%, and decreased in 9% at remission. Conclusions: In a study of bilateral ECT, the ST did not rise conclusively with remission.
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